Saberianpour, Shirin and Santin, Matteo and Nicolaou, Georgina (2025) A biomimetic macromolecular platform for tissue healing and diagnostics at medical device interfaces: a personalised wound dressing model Acronym: MyDress -Antimicrobial Dendron-functionalised Wound Dressings. [Data Collection]
Project Description
The project has developed and tested a new class of antimicrobial branched peptides that can be used both as soluble form or for the functionalisation of clinically-available or novel wound dressings. The work shows the antimicrobial activity of these branched poly(epsilon-lysine) peptides, known as dendrons, against Staphylococcus aureus. These peptides were shown to be able to have bactericidal activity on bacterium planktonic cultures as well as to prevent and eradicate biofilms of the same species. A link between the increasing number of the dendron molecular branching and the antibacterial activity against Staphylococcus aureus was demonstrated.
| Uncontrolled Keywords: | wound dressings, wound infections, biomaterials, hyperbranched peptides, dendrons, antibacterial properties, staphylococcus aureus, Pseudomonas aeruginosa. |
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| Subjects: | B Subjects allied to medicine > B170 Podiatry B Subjects allied to medicine > B700 Nursing B Subjects allied to medicine > B800 Medical technology C Biological sciences > C510 Applied microbiology |
| Departments: | School of Applied Sciences |
| Depositing User: | Matteo Santin |
| Date Deposited: | 15 Jul 2025 12:54 |
| Last Modified: | 15 Jul 2025 12:55 |
| Researchers (inc. External): |
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https://orcid.org/0000-0002-6724-411X
